製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Aph 1b
  • 特異性
    ab116657 does not cross react to other component of gamma secretase complex nor with other proteins.
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Caenorhabditis elegans
  • 免疫原

    Synthetic peptide corresponding to a region near the C terminal amino acids 235-257 of Human Aph 1b.

  • 特記事項


    ab116657 also labels the anterior pharynx defective 1 homolog B in C. elegans.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab116657 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500. Predicted molecular weight: 28 kDa.
ELISA 1/10000.

ターゲット情報

  • 機能
    Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
  • 組織特異性
    Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
  • 配列類似性
    Belongs to the APH-1 family.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Anterior pharynx defective 1 homolog B (C. elegans) antibody
    • Anterior pharynx defective 1 homolog B antibody
    • Anterior pharynx defective 1B like antibody
    • Anterior pharynx defective 1b short splicing variant antibody
    • APH 1B antibody
    • Aph 1beta antibody
    • APH-1b antibody
    • Aph-1beta antibody
    • Aph1 beta antibody
    • aph1b antibody
    • APH1B_HUMAN antibody
    • Aph1beta antibody
    • DKFZp564D0372 antibody
    • Gamma secretase subunit APH 1B antibody
    • Gamma secretase subunit APH1B antibody
    • Gamma secretase sununit antibody
    • Gamma-secretase subunit Aph-1b antibody
    • Presenilin stabilisation factor like antibody
    • Presenilin-stabilization factor-like antibody
    • PRO 1328 antibody
    • PRO1328 antibody
    • PSFL antibody
    • TAAV 688 antibody
    • TAAV688 antibody
    see all

プロトコール

参考文献

This product has been referenced in:
  • Tanveer R  et al. The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-ß and in the Cortex of Aged Rats. J Biol Chem 287:34709-21 (2012). WB ; Rat . Read more (PubMed: 22891244) »

See 1 Publication for this product

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