製品の概要

  • 製品名Anti-Apg7 antibody
    Apg7 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Apg7
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Arabidopsis thaliana
  • 免疫原

    Full length protein produced in E.coli.

アプリケーション

Our Abpromise guarantee covers the use of ab99001 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 78 kDa.

ターゲット情報

  • 機能E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
  • 組織特異性Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
  • 配列類似性Belongs to the ATG7 family.
  • ドメインThe C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12.
    The N-terminal FAP motif (residues 15 to 17) is essential for the formation of the ATG89-PE and ATG5-ATG12 conjugates.
  • 翻訳後修飾Acetylated by EP300.
  • 細胞内局在Cytoplasm. Preautophagosomal structure. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
  • Information by UniProt
  • 参照データベース
    • 別名
      • 1810013K23Rik antibody
      • Apg 7 antibody
      • APG7 autophagy 7 like antibody
      • APG7 autophagy 7-like (S. cerevisiae) antibody
      • APG7 like antibody
      • APG7, S. cerevisiae, homolog of antibody
      • APG7-like antibody
      • APG7L antibody
      • ATG 7 antibody
      • ATG12-activating enzyme E1 ATG7 antibody
      • ATG7 antibody
      • ATG7 autophagy related 7 homolog (S. cerevisiae) antibody
      • ATG7 autophagy related 7 homolog antibody
      • ATG7_HUMAN antibody
      • Atg7l antibody
      • Autophagy 7, S. cerevisiae, homolog of antibody
      • Autophagy related protein 7 antibody
      • Autophagy-related 7 (yeast) antibody
      • Autophagy-related protein 7 antibody
      • DKFZp434N0735 antibody
      • GSA 7 antibody
      • GSA7 antibody
      • hAGP7 antibody
      • Ubiquitin activating enzyme E1 like protein antibody
      • Ubiquitin-activating enzyme E1-like protein antibody
      • Ubiquitin-like modifier-activating enzyme ATG7 antibody
      see all

    Anti-Apg7 antibody (ab99001) 使用論文

    ab99001 has not yet been referenced specifically in any publications.

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