製品の概要

  • 製品名Anti-APCDD1 antibody
    APCDD1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to APCDD1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Chicken, Human
  • 免疫原

    Synthetic peptide derived from within residues 400-500 of Human APCDD1

  • ポジティブ・コントロール
    • Human heart lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.1% Sodium Azide
    Constituents: 30% Glycerol, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab77476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 59 kDa.

ターゲット情報

  • 機能Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
  • 組織特異性Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
  • 関連疾患Defects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
  • 配列類似性Belongs to the APCDD1 family.
  • 翻訳後修飾N-Glycosylated.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Adenomatosis polyposis coli down regulated 1 antibody
    • Adenomatosis polyposis coli down regulated 1 protein antibody
    • Adenomatosis polyposis coli down-regulated 1 protein antibody
    • APCD1_HUMAN antibody
    • APCDD 1 antibody
    • APCDD1 antibody
    • B7323 antibody
    • DRAPC1 antibody
    • FP7019 antibody
    • HHS antibody
    • HTS antibody
    • hypoptrichosis simplex antibody
    • Protein APCDD1 antibody
    see all

Anti-APCDD1 antibody 画像

  • Anti-APCDD1 antibody (ab77476) at 0.5 µg/ml + Human heart lysate

    Predicted band size : 59 kDa
    Observed band size : 59 kDa
    Additional bands at : 46 kDa,64 kDa. We are unsure as to the identity of these extra bands.

Anti-APCDD1 antibody (ab77476) 使用論文

ab77476 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Mouse Tissue lysate - whole (nerve)
Loading amount 40 µg
Specification nerve
Gel Running Conditions Reduced Denaturing
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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投稿 Jun 23 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"