Anti-APCDD1 抗体 (ab73063)

製品の概要

• 製品名Anti-APCDD1 antibody
  APCDD1 一次抗体 製品一覧
• 製品の詳細
  Mouse polyclonal to APCDD1
• アプリケーション適用あり: WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Full length human APCDD1 protein (NP_694545.1).

• ポジティブ･コントロール
  • APCDD1 transfected 293T cell lysate.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファーPreservative: None
  Constituents: 1X PBS, pH 7.2
• Concentration information loading...
• 精製度Protein A purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Stem Cells
  • Signaling Pathways
  • Wnt
  • Surface Molecules

  • Cancer
  • Signal transduction
  • Other

関連製品

• Compatible Secondaries
  • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
  • Goat Anti-Mouse IgG H&L (HRP) (ab205719)

アプリケーション

ターゲット情報

• 機能Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
• 組織特異性Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
• 関連疾患Defects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
• 配列類似性Belongs to the APCDD1 family.
• 翻訳後修飾N-Glycosylated.
• 細胞内局在Cell membrane.

• Target information above from: UniProt accession Q8J025 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 147495 Human
  • Omim: 607479 Human
  • SwissProt: Q8J025 Human
  • Unigene: 293274 Human
• 別名
  • Adenomatosis polyposis coli down regulated 1 antibody
  • Adenomatosis polyposis coli down regulated 1 protein antibody
  • Adenomatosis polyposis coli down-regulated 1 protein antibody

  • APCD1_HUMAN antibody
  • APCDD 1 antibody
  • APCDD1 antibody
  • B7323 antibody
  • DRAPC1 antibody
  • FP7019 antibody
  • HHS antibody
  • HTS antibody
  • hypoptrichosis simplex antibody
  • Protein APCDD1 antibody

  see all