-
機能
Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
-
組織特異性
Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
-
関連疾患
Defects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
-
配列類似性
Belongs to the APCDD1 family.
-
翻訳後修飾
N-Glycosylated.
-
細胞内局在
Cell membrane.
-
Information by UniProt
-
参照データベース
-
別名
- Adenomatosis polyposis coli down regulated 1 antibody
- Adenomatosis polyposis coli down regulated 1 protein antibody
- Adenomatosis polyposis coli down-regulated 1 protein antibody
- APCD1_HUMAN antibody
- APCDD 1 antibody
- APCDD1 antibody
- B7323 antibody
- DRAPC1 antibody
- FP7019 antibody
- HHS antibody
- HTS antibody
- hypoptrichosis simplex antibody
- Protein APCDD1 antibody
see all