製品の概要
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製品名Anti-APCDD1 antibody
APCDD1 一次抗体 製品一覧 -
製品の詳細Mouse polyclonal to APCDD1
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由来種Mouse
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アプリケーション適用あり: WBmore details
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種交差性交差種: Human
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免疫原
Full length human APCDD1 protein (NP_694545.1).
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ポジティブ･コントロール
- APCDD1 transfected 293T cell lysate.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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バッファーPreservative: None
Constituents: 1X PBS, pH 7.2 -
Concentration information loading... -
精製度Protein A purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab73063 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 59 kDa. |
ターゲット情報
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機能Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
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組織特異性Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
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関連疾患Defects in APCDD1 are a cause of hypotrichosis simplex (HTS) [MIM:605389]. HTS is a rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age.
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配列類似性Belongs to the APCDD1 family.
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翻訳後修飾N-Glycosylated.
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細胞内局在Cell membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 147495 Human
- Omim: 607479 Human
- SwissProt: Q8J025 Human
- Unigene: 293274 Human
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別名
- Adenomatosis polyposis coli down regulated 1 antibody
- Adenomatosis polyposis coli down regulated 1 protein antibody
- Adenomatosis polyposis coli down-regulated 1 protein antibody
see all
画像
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Western blot - Anti-APCDD1 antibody (ab73063)All lanes : Anti-APCDD1 antibody (ab73063) at 1 µg/ml
Lane 1 : APCDD1 transfected 293T cell lysate
Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 59 kDa
Observed band size: 70 kDa (why is the actual band size different from the predicted?)
プロトコール
参考文献
This product has been referenced in:
- Cho SG APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Oncol Lett 14:4845-4852 (2017). Read more (PubMed: 29085490) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"