This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

製品の概要

  • 製品名Anti-Apc1 antibody
    Apc1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Apc1

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 特異性This affinity purified antibody is directed against human APC1 at the S355 residue. This antibody is pan reactive for both phosphorylated and non-phosphorylated APC1 at the S355 residue.
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide: SRAHSpPALG conjugated to KLH, corresponding to amino acids 351-359 of Human Apc1.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.01% Sodium Azide
    Constituents: 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7.2
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)The product was affinity purified from monospecific antiserum by immunoaffinity purification. Antiserum was purified against the non-phosphorylated form of the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

  • 追加情報peptide ELISA: 1/80000 (determined against 0.1 µg of the phosphorylated and non-phosphorylated forms of the immunizing peptide). Approximately equivalent staining is seen when both the phosphorylated and non-phosphorylated form of the immunizing peptide are bound to the ELISA plate.

    We have tested this antibody on various human tissue lysates and have as yet detected no bands of the appropriate size, however we have seen low background.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
    • パスウェイProtein modification; protein ubiquitination.
    • 配列類似性Belongs to the APC1 family.
      Contains 4 PC repeats.
    • 翻訳後修飾Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.
    • Information by UniProt
    • 参照データベース
    • 別名
      • ANAPC 1 antibody
      • Anapc1 antibody
      • Anaphase promoting complex subunit 1 antibody
      • anaphase-promoting complex 1 (meiotic checkpoint regulator) antibody
      • Anaphase-promoting complex subunit 1 antibody
      • Apc 1 antibody
      • APC1 antibody
      • APC1_HUMAN antibody
      • Cyclosome subunit 1 antibody
      • MCPR antibody
      • Meiotic checkpoint regulator antibody
      • Mitotic checkpoint regulator antibody
      • Protein Tsg 24 antibody
      • Protein Tsg24 antibody
      • Testis-specific gene 24 protein antibody
      • TSG 24 antibody
      • TSG24 antibody
      see all

    Anti-Apc1 antibody (ab14207) 使用論文

    ab14207 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"