Anti-AP4M1 抗体 (ab96306)
Key features and details
- Rabbit polyclonal to AP4M1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-AP4M1 antibody -
製品の詳細
Rabbit polyclonal to AP4M1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow -
免疫原
Recombinant fragment, corresponding to a region within the internal sequence amino acids 70-265 of Human AP4M1.
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ポジティブ・コントロール
- 293T, A431, Jurkat, Raji cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab96306の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 50 kDa.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 50 kDa. |
ターゲット情報
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機能
Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. -
組織特異性
Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung. -
関連疾患
Defects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3) [MIM:612936]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture. -
配列類似性
Belongs to the adaptor complexes medium subunit family.
Contains 1 MHD (mu homology) domain. -
ドメイン
Interacts specifically with tyrosine-based sorting signals. -
細胞内局在
Golgi apparatus > trans-Golgi network. Membrane > coated pit. Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells. - Information by UniProt
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参照データベース
- Entrez Gene: 768040 Cow
- Entrez Gene: 9179 Human
- Entrez Gene: 11781 Mouse
- Entrez Gene: 304344 Rat
- Omim: 602296 Human
- SwissProt: Q29RY8 Cow
- SwissProt: O00189 Human
- SwissProt: Q9JKC7 Mouse
see all -
別名
- Adapter-related protein complex 4 mu-1 subunit antibody
- Adaptor related protein complex 4 mu 1 subunit antibody
- Adaptor related protein complex AP 4 mu4 subunit antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab96306 は 2 報の論文で使用されています。
- Contu VR et al. Lysosomal targeting of SIDT2 via multiple YxxF motifs is required for SIDT2 function in the process of RNautophagy. J Cell Sci 130:2843-2853 (2017). PubMed: 28724756
- Toh WH et al. Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway. Traffic 18:159-175 (2017). PubMed: 28000370