Anti-AP1S2 抗体 (ab97590)
Key features and details
- Rabbit polyclonal to AP1S2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-AP1S2 antibody
AP1S2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to AP1S2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Cow, Zebrafish -
免疫原
Recombinant fragment containing a sequence corresponding to a region within amino acids 1-122 of Human AP1S2 (NP_003907).
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ポジティブ・コントロール
- Raji whole cell lysate; A431 cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab97590の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 19 kDa.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 19 kDa. |
ターゲット情報
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機能
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. -
組織特異性
Widely expressed. -
関連疾患
Defects in AP1S2 are the cause of mental retardation X-linked type 59 (MRX59) [MIM:300630]. It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. MRX59 consists of a mild-to-profound mental retardation. Other features includes hypotonia early in life and delay in walking. -
配列類似性
Belongs to the adaptor complexes small subunit family. -
細胞内局在
Golgi apparatus. Cytoplasmic vesicle membrane. Membrane > clathrin-coated pit. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. - Information by UniProt
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参照データベース
- Entrez Gene: 8905 Human
- Entrez Gene: 108012 Mouse
- Entrez Gene: 327237 Zebrafish
- Omim: 300629 Human
- SwissProt: P56377 Human
- SwissProt: Q9DB50 Mouse
- Unigene: 653504 Human
- Unigene: 720688 Human
see all -
別名
- Adapter related protein complex 1 sigma 1B subunit antibody
- Adapter-related protein complex 1 sigma-1B subunit antibody
- Adaptor protein complex AP 1 sigma 1B subunit antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab97590 は 1 報の論文で使用されています。
- Field MJ et al. Different types of disease-causing noncoding variants revealed by genomic and gene expression analyses in families with X-linked intellectual disability. Hum Mutat 42:835-847 (2021). PubMed: 33847015