製品の概要

  • 製品名Anti-ANTXR2 antibody
    ANTXR2 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to ANTXR2
  • 特異性This antibody is expected to recognize both reported isoforms (NP_477520.2; NP_001139266.1).
  • アプリケーション適用あり: WB, Flow Cytmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Cow, Dog
  • 免疫原

    Synthetic peptide:

    HEGLKLANEQIQK

    by a Cysteine residue linker, corresponding to internal sequence amino acids 121-133 of Human ANTXR2(NP_477520.2; NP_001139266.1)

  • ポジティブ・コントロール
    • Human, Mouse and Rat kidney lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab101711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 54 kDa.
Flow Cyt Use at an assay dependent concentration. PubMed: 24742682

ab37373 - Goat polyclonal IgG, is suitable for use as an isotype control with this antibody.



ab37373-Goat polyclonal IgG, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Necessary for cellular interactions with laminin and the extracellular matrix.
  • 組織特異性Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
  • 関連疾患Defects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH) [MIM:236490]. This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures.
    Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF) [MIM:228600]. JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility.
  • 配列類似性Belongs to the ATR family.
    Contains 1 VWFA domain.
  • ドメインBinding to PA seems to be effected through the VWA domain.
  • 細胞内局在Secreted; Cell membrane. Expressed at the cell surface and Endoplasmic reticulum membrane. Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2310046B19Rik antibody
    • Anthrax toxin receptor 2 antibody
    • ANTR2_HUMAN antibody
    • Antxr2 antibody
    • AW561899 antibody
    • Capillary morphogenesis gene 2 protein antibody
    • Capillary morphogenesis protein 2 antibody
    • CMG 2 antibody
    • CMG-2 antibody
    • CMG2 antibody
    • FLJ31074 antibody
    • HFS antibody
    • ISH antibody
    • JHF antibody
    • MGC111533 antibody
    • MGC45856 antibody
    see all

Anti-ANTXR2 antibody 画像

  • Anti-ANTXR2 antibody (ab101711) at 0.3 µg/ml + Mouse Kidney lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 54 kDa

Anti-ANTXR2 antibody (ab101711) 使用論文

This product has been referenced in:
  • Arévalo MT  et al. Targeted Silencing of Anthrax Toxin Receptors Protects against Anthrax Toxins. J Biol Chem 289:15730-15738 (2014). Flow Cyt, Blocking ; Human . Read more (PubMed: 24742682) »

See 1 Publication for this product

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