Anti-Antithrombin III 抗体 [EPR5371] (ab124808)
製品の概要
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製品名Anti-Antithrombin III antibody [EPR5371]
Antithrombin III 一次抗体 製品一覧 -
製品の詳細Rabbit monoclonal [EPR5371] to Antithrombin III
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由来種Rabbit
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アプリケーション適用あり: ICC/IF, WBmore details
適用なし: IHC-P or IP -
種交差性交差種: Human
非交差種: Mouse, Rat -
免疫原
Synthetic peptide within Human Antithrombin III aa 1-100. The exact sequence is proprietary.
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ポジティブ･コントロール
- Human plasma, ovary cancer and Human testis lysates
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特記事項
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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バッファーPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
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Concentration information loading... -
ポリ/モノモノクローナル
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クローン名EPR5371
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アイソタイプIgG
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研究分野
アプリケーション
Our Abpromise guarantee covers the use of ab124808 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC/IF | 1/50 - 1/100. | |
| WB | 1/1000 - 1/10000. Detects a band of approximately 55 kDa (predicted molecular weight: 52 kDa). |
ターゲット情報
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機能Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
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組織特異性Found in plasma.
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関連疾患Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
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配列類似性Belongs to the serpin family.
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翻訳後修飾Phosphorylation sites are present in the extracelllular medium.
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細胞内局在Secreted > extracellular space.
- Information by UniProt
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参照データベース
- Entrez Gene: 462 Human
- Omim: 107300 Human
- SwissProt: P01008 Human
- Unigene: 75599 Human
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別名
- ANT3_HUMAN antibody
- Antithrombin antibody
- Antithrombin III antibody
see all
画像
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![Western blot - Anti-Antithrombin III antibody [EPR5371] (ab124808)](http://a.abcam.com/ps/datasheet/images/124/ab124808/Antithrombin-III-Primary-antibodies-ab124808-1.jpg)
Western blot - Anti-Antithrombin III antibody [EPR5371] (ab124808)All lanes : Anti-Antithrombin III antibody [EPR5371] (ab124808) at 1/1000 dilution
Lane 1 : Human plasma lysate
Lane 2 : Human ovary cancer lysate
Lane 3 : Human testis lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 52 kDa
Observed band size: 55 kDa (why is the actual band size different from the predicted?)
参考文献
ab124808 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"