Anti-Antithrombin III 抗体 [EPR5371] (ab124808)

製品の概要

• 製品名
  Anti-Antithrombin III antibody [EPR5371]
  Antithrombin III 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [EPR5371] to Antithrombin III
• アプリケーション
  適用あり: ICC/IF, WBmore details
  適用なし: IHC-P or IP
• 種交差性
  交差種: Human
  非交差種: Mouse, Rat
• 免疫原

  Synthetic peptide (the amino acid sequence is considered to be commercially sensitive)

• ポジティブ･コントロール
  • Human plasma, ovary cancer and Human testis lysates
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• バッファー
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Concentration information loading...
• ポリ/モノ
  モノクローナル
• クローン名
  EPR5371
• アイソタイプ
  IgG
• 研究分野
  • Cardiovascular
  • Blood
  • Serum Proteins

  • Cardiovascular
  • Blood
  • Coagulation
  • Regulatory

アプリケーション

ターゲット情報

• 機能
  Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
• 組織特異性
  Found in plasma.
• 関連疾患
  Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
• 配列類似性
  Belongs to the serpin family.
• 翻訳後修飾
  Phosphorylation sites are present in the extracelllular medium.
• 細胞内局在
  Secreted > extracellular space.

• Target information above from: UniProt accession P01008 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 462 Human
  • Omim: 107300 Human
  • SwissProt: P01008 Human
  • Unigene: 75599 Human
• 別名
  • ANT3_HUMAN antibody
  • Antithrombin antibody
  • Antithrombin III antibody

  • Antithrombin-III antibody
  • AntithrombinIII antibody
  • AT 3 antibody
  • AT III antibody
  • AT3 antibody
  • AT3D antibody
  • ATIII antibody
  • Heparin cofactor I antibody
  • MGC22579 antibody
  • Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibody
  • Serine cysteine proteinase inhibitor clade C member 1 antibody
  • Serine proteinase inhibitor clade C member 1 antibody
  • Serpin C1 antibody
  • Serpin family C member 1 antibody
  • Serpin peptidase inhibitor clade C (antithrombin) member 1 antibody
  • SERPINC1 antibody
  • THPH7 antibody

  see all

プロトコール

• Western blot protocols
• Immunocytochemistry & immunofluorescence protocols