Recombinant fragment, corresponding to amino acids 177-329 of Human Annexin II (NM_001002857).
WB: SW480 and MDA-MB-231 cell lysates
IHC-P: Human colon carcinoma tissue
製品の状態Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
機能Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
配列類似性Belongs to the annexin family. Contains 4 annexin repeats.
ドメインA pair of annexin repeats may form one binding site for calcium and phospholipid.
翻訳後修飾Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated.
細胞内局在Secreted > extracellular space > extracellular matrix > basement membrane. Melanosome. In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.