製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to ANKS1B
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 569-599 of Human ANKS1B (NP_064525.1 , NP_858056.2 , NP_690001.3).

  • ポジティブ・コントロール
    • NCI-H292 cell line lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab116083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 138 kDa.

ターゲット情報

  • 機能
    Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
    Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
    Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
  • 組織特異性
    Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
  • 配列類似性
    Contains 7 ANK repeats.
    Contains 1 PID domain.
    Contains 2 SAM (sterile alpha motif) domains.
  • 翻訳後修飾
    Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage.
  • 細胞内局在
    Cytoplasm; Nucleus; Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Nucleus. Nucleus > Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner and Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AIDA antibody
    • AIDA-1 antibody
    • Amyloid-beta protein intracellular domain-associated protein 1 antibody
    • Anks1b antibody
    • ANKS2 antibody
    • Ankyrin repeat and sterile alpha motif domain containing 1B antibody
    • Ankyrin repeat and sterile alpha motif domain-containing protein 1B antibody
    • ANS1B_HUMAN antibody
    • Cajalin 2 antibody
    • E2A-PBX1-associated protein antibody
    • EB-1 antibody
    • EB1 antibody
    • MGC26087 antibody
    see all

画像

  • Anti-ANKS1B antibody (ab116083) at 1/100 dilution + NCI-H292 cell line lysates at 35 µg

    Predicted band size : 138 kDa

プロトコール

参考文献

This product has been referenced in:
  • de Souza EE  et al. Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6. J Proteome Res 13:4074-90 (2014). Read more (PubMed: 25093993) »

See 1 Publication for this product

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