製品の概要

  • 製品名Anti-Angiotensin I antibody
    Angiotensin I 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Angiotensin I
  • アプリケーション適用あり: IP, ELISA, RIAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Sheep, Horse, Dog, Chimpanzee
  • 免疫原

    Synthetic peptide:

    C-DRVYIHPFHL

    conjugated to KLH by a Cysteine residue linker, corresponding to amino acids 34-43 of Human Angiotensin I

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53951 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.

ターゲット情報

  • 機能Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.
    Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.
    Angiotensin-3 stimulates aldosterone release.
    Angiotensin 1-7 is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
  • 組織特異性Expressed by the liver and secreted in plasma.
  • 関連疾患Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT) [MIM:145500]. Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.
    Defects in AGT are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
  • 配列類似性Belongs to the serpin family.
  • 翻訳後修飾Beta-decarboxylation of Asp-34 in angiotensin-2, by mononuclear leukocytes produces alanine. The resulting peptide form, angiotensin-A, has the same affinity for the AT1 receptor as angiotensin-2, but a higher affinity for the AT2 receptor.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AGT antibody
    • Alpha 1 antiproteinase antitrypsin antibody
    • Ang I antibody
    • Ang II antibody
    • Ang III antibody
    • Angiotensin 1 antibody
    • Angiotensin I antibody
    • Angiotensin II antibody
    • Angiotensin III antibody
    • Angiotensin-3 antibody
    • Angiotensinogen antibody
    • Angiotensinogen serpin peptidase inhibitor clade A member 8 antibody
    • ANGT_HUMAN antibody
    • ANHU antibody
    • Des-Asp[1]-angiotensin II antibody
    • FLJ92595 antibody
    • FLJ97926 antibody
    • OTTHUMP00000035878 antibody
    • Pre angiotensinogen antibody
    • Serine or cysteine proteinase inhibitor antibody
    • Serpin A8 antibody
    • SERPINA8 antibody
    see all

Anti-Angiotensin I antibody (ab53951) 使用論文

ab53951 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab53951.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"