製品の概要

製品の詳細

  • 由来Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab4936 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and FIAF, catalog ab2920. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

関連情報

  • 別名
    • Angiopoietin like 4
    • Angiopoietin related protein 4
    • Angiopoietin-like protein 4
    • Angiopoietin-related protein 4
    • ANGL4_HUMAN
    • ANGPT L2
    • ANGPT L4
    • ANGPTL2
    • Angptl4
    • ARP4
    • Fasting induced adipose factor
    • FIAF
    • HARP
    • Hepatic angiopoietin related protein
    • Hepatic fibrinogen/angiopoietin related protein
    • Hepatic fibrinogen/angiopoietin-related protein
    • HFARP
    • NL2
    • Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein
    • PGAR
    • pp1158
    • PPARG angiopoietin related protein
    • PSEC0166
    • TGQTL
    • UNQ171
    • Weakly similar to angiopoietin 1 [H.sapiens]
    see all
  • 機能Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
  • 組織特異性Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
  • 配列類似性Contains 1 fibrinogen C-terminal domain.
  • 翻訳後修飾N-glycosylated.
  • 細胞内局在Secreted. Secreted > extracellular space > extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
  • Information by UniProt

Angiopoietin-like 4 peptide (ab4936) 使用論文

ab4936 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"