製品の概要

  • 製品名Anti-Angiomotin antibody
    Angiomotin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Angiomotin
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Bat, Elephant
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 1034-1084 of Human Angiomotin (NP_001106962.1).

  • ポジティブ・コントロール
    • 293T whole cell lysates.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab117776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000 - 1/10000. Predicted molecular weight: 118 kDa.
IP Use at 2-10 µg/mg of lysate.

ターゲット情報

  • 機能Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.
  • 組織特異性Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
  • 配列類似性Belongs to the angiomotin family.
  • ドメインThe coiled coil domain interacts directly with the BAR domain of ARHGAP17.
    The angiostatin binding domain (871-1005) allows the binding to angiostatin.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cell junction > tight junction. Localized on the cell surface. May act as a transmembrane protein.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AMOT antibody
    • AMOT_HUMAN antibody
    • Angiomotin antibody
    • Angiomotin p130 isoform antibody
    • KIAA1071 antibody
    see all

Anti-Angiomotin antibody 画像

  • All lanes : Anti-Angiomotin antibody (ab117776) at 0.04 µg/ml

    Lane 1 : 293T whole cell lysates at 50 µg
    Lane 2 : 293T whole cell lysates at 15 µg
    Lane 3 : HeLa whole cell lysates at 50 µg

    Developed using the ECL technique

    Predicted band size : 118 kDa


    Exposure time : 3 seconds
  • Detection of Angiomotin by Western Blot of Immunprecipitate.
    ab117776 at 1µg/ml staining Angiomotin in 293T whole cell lysate immunoprecipitated using ab117776 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
    Detection: Chemiluminescence with exposure time of 1 second.

Anti-Angiomotin antibody (ab117776) 使用論文

ab117776 has not yet been referenced specifically in any publications.

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