製品の概要

  • 製品名Anti-Angiogenin antibody
    Angiogenin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Angiogenin
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to N terminal amino acids of Human Angiogenin

  • ポジティブ・コントロール
    • MCF-7, HeLa and SW620 Cell Lysate

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab125231 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 17 kDa.
IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

ターゲット情報

  • 機能May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
  • 組織特異性Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
  • 関連疾患Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.
  • 配列類似性Belongs to the pancreatic ribonuclease family.
  • 発生段階Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ALS9 antibody
    • AMYOTROPHIC LATERAL SCLEROSIS antibody
    • ANG 1 antibody
    • ANG antibody
    • ANG I antibody
    • ANG1 antibody
    • ANGI antibody
    • ANGI_HUMAN antibody
    • Angiogenin antibody
    • Angiogenin ribonuclease RNase A family, 5 antibody
    • Epididymis luminal protein 168 antibody
    • HEL168 antibody
    • MGC22466 antibody
    • MGC71966 antibody
    • Ribonuclease 5 antibody
    • Ribonuclease RNase A Family 5 antibody
    • RNase 5 antibody
    • RNASE4 antibody
    • RNASE5 antibody
    see all

Anti-Angiogenin antibody 画像

  • All lanes : Anti-Angiogenin antibody (ab125231) at 1 µg/ml

    Lane 1 : MCF7 lysate
    Lane 2 : HeLa lysate
    Lane 3 : SW620 lysate


    Predicted band size : 17 kDa
  • ab125231 staining human pancreas cancer tissue using Immunohistochemisty-Formalin/PFA-fixed paraffin-embedded sections.

Anti-Angiogenin antibody (ab125231) 使用論文

ab125231 has not yet been referenced specifically in any publications.

Product Wall

Abreviews
Abcam has not validated the combination of species/application used in this Abreview.
Application ChIP
Sample Human Cell lysate - other (HeLA)
Specification HeLA
Type Cross-linking (X-ChIP)
Duration of cross-linking step: 5 minute(s) and 0 second(s)
Specification of the cross-linking agent: Formaldehyde
Detection step Real-time PCR
Username

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投稿 May 14 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"