製品の概要

  • 製品名
    Anacardic acid
  • 製品の詳細
    Histone acetyltransferase (HAT) inhibitor
  • 生理活性の詳細
    Inhibits HAT activity of p300 and p300/CREB-binding protein-associated factor (pCAF) (IC50 = 8.5 and 5 μM, respectively). Suppresses NF-κB activation, inhibits IκBα phosphorylation and prohibits p65 nuclear translocation
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Omanakuttan A  et al. Anacardic acid inhibits the catalytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9. Mol Pharmacol 82:614-22 (2012). Read more (PubMed: 22745359) »
  • Sung B  et al. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis. Blood 111:4880-91 (2008). Read more (PubMed: 18349320) »
  • Balasubramanyam K  et al. Small molecule modulators of histone acetyltransferase p300. J Biol Chem 278:19134-40 (2003). Read more (PubMed: 12624111) »

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