Amyloid β peptide fragment. Aggregates and displays toxic effect in vitro. Also shows amnestic effect in vivo following i.c.v administration. Additionally binds α7-nicotinic ACh receptors with high affinity.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 1 mg/ml
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Cao Z et al. Effects of different force fields and temperatures on the structural character of abeta (12-28) Peptide in aqueous solution. Int J Mol Sci12:8259-74 (2011).
Read more (PubMed: 22174662) »
Flood JF et al. An amyloid beta-protein fragment, A beta[12-28], equipotently impairs post-training memory processing when injected into different limbic system structures. Brain Res663:271-6 (1994).
Read more (PubMed: 7874511) »
Flood JF et al. Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease. Proc Natl Acad Sci U S A88:3363-6 (1991).
Read more (PubMed: 2014256) »