Anti-Amylin/DAP 抗体 (ab103580)
Key features and details
- Rabbit polyclonal to Amylin/DAP
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Amylin/DAP antibody
Amylin/DAP 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Amylin/DAP -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein within Human Amylin/DAP aa 1-100. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: NP_000406.1 -
ポジティブ・コントロール
- Human spleen tissue lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab103580の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/1000. Predicted molecular weight: 10 kDa.
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特記事項 |
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WB
1/500 - 1/1000. Predicted molecular weight: 10 kDa. |
ターゲット情報
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機能
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. -
配列類似性
Belongs to the calcitonin family. -
ドメイン
The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation. -
翻訳後修飾
Amyloid fibrils are degraded by IDE. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 3375 Human
- Omim: 147940 Human
- SwissProt: P10997 Human
- Unigene: 46835 Human
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別名
- Amylin antibody
- DAP antibody
- Diabetes associated peptide antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (3)
ab103580 は 3 報の論文で使用されています。
- Yang Y et al. Pramlintide: A Novel Therapeutic Approach for Osteosarcoma through Metabolic Reprogramming. Cancers (Basel) 14:N/A (2022). PubMed: 36077845
- Burillo J et al. Human amylin aggregates release within exosomes as a protective mechanism in pancreatic β cells: Pancreatic β-hippocampal cell communication. Biochim Biophys Acta Mol Cell Res 1868:118971 (2021). PubMed: 33515645
- Venkatanarayan A et al. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature 517:626-30 (2015). WB . PubMed: 25409149