Anti-Amphiregulin 抗体 (ab2993)

製品の概要

  • 製品名Anti-Amphiregulin antibody
    Amphiregulin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Amphiregulin
  • アプリケーション適用あり: IPmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    A synthetic 19 mer peptide, corresponding to amino acids 8 - 26 (

    VKPPQNKTESENTSDKPKR

    ) from the secretedamphiregulin of human origin.

  • ポジティブ・コントロール
    • LS174T cells
  • 特記事項


    Amphiregulin binds to EGF Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84 amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252 amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGF alpha, AR, HB EGF, cripto 1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーpH: 7.40
    Constituents: 0.0268% PBS, 0.2% BSA
  • Concentration information loading...
  • 精製度Protein A purified
  • 一次抗体 備考Amphiregulin binds to EGF Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84 amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252 amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGF alpha, AR, HB EGF, cripto 1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab2993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 10 µg/mg of lysate.

With protein A, native.

ターゲット情報

Anti-Amphiregulin antibody (ab2993) 使用論文

ab2993 has not yet been referenced specifically in any publications.

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Thank you for your enquiry. We would like to confirm that this primary antibody is un-conjugated therefore you need an HRP-linked secondary antibody. The recommended compatible secondary antibodies are listed on the bottom section of the on-line da...

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Thank you for your enquiry. The ab2993 Amphiregulin antibody recognizes a synthetic 19 mer peptide, corresponding to amino acids 8 - 26 (VKPPQNKTESENTSDKPKR) from the secretedamphiregulin of human origin. If that amino acid sequence is present in the ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"