製品の概要

  • 製品名
    AMD3100 octahydrochloride
  • 製品の詳細
    Highly selective CXCR4 antagonist
  • 別名
    • JM 3100
  • 生理活性の詳細
    Highly selective CXCR4 receptor antagonist (IC50 = 2-20 nM). Potently inhibits SDF-1α (CXCL12) binding (IC50 = 650 nM). Displays strong anti-HIV activity in vivo and in vitro. Additionally mobilises stem cells.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • De Clercq E The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil). Biochem Pharmacol 77:1655-64 (2009). Read more (PubMed: 19161986) »
  • Rusconi S  et al. New macrocyclic amines showing activity as HIV entry inhibitors against wild type and multi-drug resistant viruses. Molecules 14:1927-37 (2009). Read more (PubMed: 19471212) »
  • Fricker SP  et al. Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4. Biochem Pharmacol 72:588-96 (2006). Read more (PubMed: 16815309) »

See all 5 Publications for this product

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