製品の概要

  • 製品名
    Anti-Alx1 antibody [3329D3a]
    Alx1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [3329D3a] to Alx1
  • アプリケーション
    適用あり: WB, Dot blotmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment derived from internal sequence of human Alx1

  • ポジティブ・コントロール
    • Recombinant human Alx1.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab70604 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Predicted molecular weight: 37 kDa.
Dot blot Use at an assay dependent dilution.

ターゲット情報

  • 機能
    Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development.
  • 組織特異性
    Cartilage and cervix tissue.
  • 関連疾患
    Defects in ALX1 are the cause of frontonasal dysplasia type 3 (FND3) [MIM:613456]. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.
  • 配列類似性
    Belongs to the paired homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 翻訳後修飾
    Acetylated at Lys-131 by EP300, leading to increased interaction with EP300 and enhances transcriptional activation activity.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ALX homeobox 1 antibody
    • ALX homeobox protein 1 antibody
    • ALX1 antibody
    • ALX1_HUMAN antibody
    • CART 1 antibody
    • CART-1 antibody
    • CART1 antibody
    • Cartilage homeoprotein 1 antibody
    • Cartilage paired class homeoprotein 1 antibody
    • FND3 antibody
    see all

画像

  • Anti-Alx1 antibody [3329D3a] (ab70604) + immunising recombinant protein

    Predicted band size : 37 kDa
    Observed band size : 37 kDa

プロトコール

参考文献

ab70604 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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