Anti-alpha smooth muscle Actin 抗体 [1A4], prediluted (ab8207)

製品の概要

  • 製品名
    Anti-alpha smooth muscle Actin antibody [1A4], prediluted
    alpha smooth muscle Actin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [1A4] to alpha smooth muscle Actin, prediluted
  • 由来種
    Mouse
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Chicken, Cow, Pig, Frog
  • 免疫原

    Synthetic peptide corresponding to Human alpha smooth muscle Actin (N terminal).
    Database link: P62736

  • ポジティブ・コントロール
    • IHC: Human small intestine tissue.
  • 特記事項

    This antibody reacts with smooth muscle cells of blood vessels and parenchymal tissue of intestine, testis and ovary.

    To identify and differentiate tumors of myogenic origin.

     

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab8207 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • 関連疾患
    Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
  • 配列類似性
    Belongs to the actin family.
  • 細胞内局在
    Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 参照データベース
  • 別名
    • a actin antibody
    • AAT6 antibody
    • ACTA_HUMAN antibody
    • ACTA2 antibody
    • Actin alpha 2 smooth muscle aorta antibody
    • Actin aortic smooth muscle antibody
    • Actin, aortic smooth muscle antibody
    • ACTSA antibody
    • ACTVS antibody
    • Alpha 2 actin antibody
    • Alpha actin 2 antibody
    • Alpha cardiac actin antibody
    • alpha sma antibody
    • Alpha-actin-2 antibody
    • Cell growth inhibiting gene 46 protein antibody
    • Cell growth-inhibiting gene 46 protein antibody
    • GIG46 antibody
    • Growth inhibiting gene 46 antibody
    • MYMY5 antibody
    see all

画像

  • Formalin-fixed, paraffin-embedded human small intestine tissue stained for alpha smooth muscle Actin using ab8207 in immunohistochemical analysis.

参考文献

This product has been referenced in:
  • Ikutani M  et al. Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy. JCI Insight 2:e90721 (2017). Read more (PubMed: 28405615) »
  • Li M  et al. Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-?. Am J Cardiovasc Dis 6:118-28 (2016). Read more (PubMed: 27679746) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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