Anti-Alpha Skeletal Muscle Actin 抗体 [5C5.F8.C7] (ab74543)


  • 製品名Anti-Alpha Skeletal Muscle Actin antibody [5C5.F8.C7]
    Alpha Skeletal Muscle Actin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [5C5.F8.C7] to Alpha Skeletal Muscle Actin
  • 特異性ab74543 is highly specific and shows no cross-reaction with smooth muscle actin. This antibody reacts with sarcomeric actins of normal tissues and neoplasms derived from such tissues (i.e. rhabdomyosarcomas).
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    N-terminal decapeptide of human skeletal muscle Actin

  • ポジティブ・コントロール
    • Human skeletal muscle tissue.



Our Abpromise guarantee covers the use of ab74543 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報IHC-P: 1/50 for 30 min at RT.
    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
    • 関連疾患Defects in ACTA1 are the cause of nemaline myopathy type 3 (NEM3) [MIM:161800]. A form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-or rod-like structures in muscle fibers on histologic examination. The phenotype at histological level is variable. Some patients present areas devoid of oxidative activity containg (cores) within myofibers. Core lesions are unstructured and poorly circumscribed.
      Defects in ACTA1 are a cause of myopathy congenital with excess of thin myofilaments (MPCETM) [MIM:161800]. A congenital muscular disorder characterized at histological level by areas of sarcoplasm devoid of normal myofibrils and mitochondria, and replaced with dense masses of thin filaments. Central cores, rods, ragged red fibers, and necrosis are absent.
      Defects in ACTA1 are a cause of congenital myopathy with fiber-type disproportion (CFTD) [MIM:255310]; also known as congenital fiber-type disproportion myopathy (CFTDM). CFTD is a genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
    • 配列類似性Belongs to the actin family.
    • 細胞内局在Cytoplasm > cytoskeleton.
    • Information by UniProt
    • 参照データベース
    • 別名
      • a actin antibody
      • ACTA antibody
      • ACTA1 antibody
      • ACTC antibody
      • ACTC1 antibody
      • Actin alpha cardiac muscle antibody
      • Actin, alpha skeletal muscle antibody
      • ACTS_HUMAN antibody
      • Alpha actin 1 antibody
      • Alpha-actin-1 antibody
      • ASMA antibody
      • Cardiac muscle alpha actin 1 antibody
      • MPFD antibody
      • Skeletal muscle alpha actin 1 antibody
      see all

    Anti-Alpha Skeletal Muscle Actin antibody [5C5.F8.C7] 画像

    • ab74543 at 1/50 dilution staining skeletal muscle Actin in Human skeletal muscle by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

    Anti-Alpha Skeletal Muscle Actin antibody [5C5.F8.C7] (ab74543) 使用論文

    ab74543 has not yet been referenced specifically in any publications.

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