製品の概要

  • 製品名Anti-alpha Sarcoglycan antibody
    alpha Sarcoglycan 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to alpha Sarcoglycan
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide derived from an internal sequence of Human alpha Sarcoglycan.

  • ポジティブ・コントロール
    • Jurkat, HepG2 and HeLa cell extracts.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab92522 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab92522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 43 kDa.

ターゲット情報

  • 機能Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • 組織特異性Most strongly expressed in skeletal muscle. Also expressed in cardiac muscle and, at much lower levels, in lung. In the fetus, most abundant in cardiac muscle and, at lower levels, in lung. Also detected in liver and kidney. Not expressed in brain.
  • 関連疾患Defects in SGCA are the cause of limb-girdle muscular dystrophy type 2D (LGMD2D) [MIM:608099]; also known as Duchenne-like muscular dystrophy autosomal recessive type 2 or severe childhood autosomal recessive muscular dystrophy (SCARMD). LGMD2D is an autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency. The phenotype is less severe than LGMD2C.
  • 配列類似性Belongs to the sarcoglycan alpha/epsilon family.
  • 細胞内局在Cell membrane > sarcolemma. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 50 DAG antibody
    • 50 kDa dystrophin associated glycoprotein antibody
    • 50 kDa dystrophin-associated glycoprotein antibody
    • 50DAG antibody
    • 50kD DAG antibody
    • 59kDa antibody
    • A2 antibody
    • adhalin antibody
    • ADL antibody
    • Alpha SG antibody
    • Alpha-sarcoglycan antibody
    • Alpha-SG antibody
    • Asg antibody
    • DAG2 antibody
    • DMDA2 antibody
    • Dystroglycan 2 antibody
    • Dystroglycan-2 antibody
    • LGMD2D antibody
    • sarcoglycan, alpha (dystrophin-associated glycoprotein) antibody
    • SCARMD1 antibody
    • Sgca antibody
    • SGCA_HUMAN antibody
    see all

Anti-alpha Sarcoglycan antibody 画像

  • All lanes : Anti-alpha Sarcoglycan antibody (ab92522) at 1/500 dilution

    Lane 1 : Jurkat cell extracts
    Lane 2 : HepG2 cell extracts
    Lane 3 : HeLa cell extracts
    Lane 4 : HeLa cell extracts with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 43 kDa

Anti-alpha Sarcoglycan antibody (ab92522) 使用論文

ab92522 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab92522.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"