α-MSH (α-Melanocyte-stimulating hormone) (ab120189)

製品の概要

  • 製品名
    α-MSH (α-Melanocyte-stimulating hormone)
  • 製品の詳細
    Endogenous melanocortin receptor agonist
  • 別名
    • α-Melanocyte-stimulating hormone
    • α-Melanotropin
  • 生理活性の詳細
    Endogenous melanocortin receptor agonist involved in feeding, homeostasis, body weight and inflammation.
  • 精製度
    > 95%

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab120189 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Functional Studies Use at an assay dependent concentration.

画像

  • ab24851 staining cAMP in MALME-3M cells treated with α-MSH (ab120189), by ICC/IF. Increase of cAMP correlates with increased concentration of α-MSH as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120189 (α-MSH) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab24851 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

参考文献

This product has been referenced in:
  • Luger TA & Brzoska T alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Ann Rheum Dis 66 Suppl 3:iii52-5 (2007). Read more (PubMed: 17934097) »
  • Wu CS  et al. Peripherally administered desacetyl alpha-MSH and alpha-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression. Am J Physiol Endocrinol Metab 291:E1372-80 (2006). Read more (PubMed: 16868223) »
  • Wikberg JE Melanocortin receptors: perspectives for novel drugs. Eur J Pharmacol 375:295-310 (1999). Read more (PubMed: 10443584) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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