The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
追加情報WB: Use at a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 18-19 kDa (predicted molecular weight: 20 kDa).
Peptide ELISA: antibody detection limit dilution 1:128,000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能May contribute to the transparency and refractive index of the lens.
組織特異性Lens as well as other tissues.
関連疾患Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.
配列類似性Belongs to the small heat shock protein (HSP20) family.
細胞内局在Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.