Anti-alpha A + alpha B Crystallin 抗体 (ab63998)

製品の概要

  • 製品名Anti-alpha A + alpha B Crystallin antibody
    Alpha A + alpha B Crystallin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to alpha A + alpha B Crystallin
  • アプリケーション適用あり: IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Cow, Human
  • 免疫原

    Bovine alpha/beta crystalin which has greater than 80% homology with human alpha/beta crystalin.

  • ポジティブ・コントロール
    • Stains Rosenthal fibre accumulation in astrocytes in human neurological trauma.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab63998 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/1000 - 1/4000.
ICC/IF 1/100 - 1/400.

ターゲット情報

  • 関連性Crystallins are separated into two classes: taxon specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Alpha crystallins are composed of two gene products: alpha A and alpha B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture.
  • 細胞内局在Cytoplasmic
  • 参照データベース
  • 別名
    • Alpha crystallin A chain antibody
    • Alpha crystallin B chain antibody
    • CRYA1 antibody
    • CRYA2 antibody
    • CRYAA antibody
    • CRYAB antibody
    • Heat shock protein beta 4 antibody
    • Heat shock protein beta 5 antibody
    • HspB4 antibody
    • HspB5 antibody
    • Rosenthal fiber component antibody
    see all

Anti-alpha A + alpha B Crystallin antibody 画像

  • Ab63998 (1:2000) staining of human brain tissue showing aß crystallin accumulation in Rosenthal fibres. Secondary antibody biotinylated Goat anti-rabbit (1/2000). (A) Shows the early stages of aß crystallin accumulation in astrocytes, (B) astrocyte begins to hypertrophy with aß crystallin accumulation, (C) the astrocyte begins to further hypertrophy and cell structure is lost.

Anti-alpha A + alpha B Crystallin antibody (ab63998) 使用論文

ab63998 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"