Anti-alpha Defensin 5 抗体 [8C8] (ab90802)
Key features and details
- Mouse monoclonal [8C8] to alpha Defensin 5
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG2b
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
-
製品名
Anti-alpha Defensin 5 antibody [8C8]
alpha Defensin 5 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [8C8] to alpha Defensin 5 -
由来種
Mouse -
特異性
ab90802 recognizes the propeptide and the partially processed forms (aa 36-94 and 56-94), but it hardly recognizes mature peptide. No cross reactivity with HD6, lysozyme, or sPLA2 has be detected. -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Chimpanzee -
免疫原
Recombinant fragment corresponding to Human alpha Defensin 5 aa 20-94.
Sequence:ESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRT GRCATRESLSGVCEISGRLYRLCCR
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading...
-
精製度
Protein A purified -
特記事項(精製)
ab90802 was filtered through a 0.2 µm filter. -
ポリ/モノ
モノクローナル -
クローン名
8C8 -
アイソタイプ
IgG2b -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab90802の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P | (2) |
1/50.
|
特記事項 |
---|
IHC-P
1/50. |
ターゲット情報
-
機能
Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. -
組織特異性
Paneth cells of the small intestine (at protein level). -
配列類似性
Belongs to the alpha-defensin family. -
翻訳後修飾
Glycosylated. -
細胞内局在
Secreted. Cytoplasmic vesicle > secretory vesicle. Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form. - Information by UniProt
-
参照データベース
- Entrez Gene: 463972 Chimpanzee
- Entrez Gene: 1670 Human
- Omim: 600472 Human
- SwissProt: Q5G861 Chimpanzee
- SwissProt: Q01523 Human
- Unigene: 655233 Human
-
別名
- alpha 5 antibody
- DEF5 antibody
- DEF5_HUMAN antibody
see all
画像
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (2)
ab90802 は 2 報の論文で使用されています。
- Liszt KI et al. Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity. J Clin Invest 132:N/A (2022). PubMed: 34784295
- Spencer JD et al. Human alpha defensin 5 expression in the human kidney and urinary tract. PLoS One 7:e31712 (2012). IHC ; Human . PubMed: 22359618