Anti-alpha 2a Adrenergic Receptor 抗体 (ab45871)


  • 製品名
    Anti-alpha 2a Adrenergic Receptor antibody
    alpha 2a Adrenergic Receptor 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to alpha 2a Adrenergic Receptor
  • アプリケーション
    適用あり: ICC/IFmore details
  • 種交差性
    交差種: Mouse, Rat
    交差が予測される動物種: Dog, Human
  • 免疫原

    Synthetic peptide:


    , corresponding to Internal sequence amino acids 246-258 of Human alpha 2a Adrenergic Receptor

  • ポジティブ・コントロール
    • Human brain lysate.


  • 製品の状態
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
  • アイソタイプ
  • 研究分野


Our Abpromise guarantee covers the use of ab45871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use at an assay dependent dilution. PubMed: 19126537


  • 機能
    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
  • 配列類似性
    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.
  • 細胞内局在
    Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADA2A_HUMAN antibody
    • ADRA2 antibody
    • ADRA2A antibody
    • ADRA2R antibody
    • ADRAR antibody
    • Adrenergic alpha 2A receptor antibody
    • Alpha 2 adrenergic receptor subtype C10 antibody
    • Alpha 2A adrenergic receptor antibody
    • Alpha 2AAR subtype C10 antibody
    • Alpha-2 adrenergic receptor subtype C10 antibody
    • alpha-2-adrenergic receptor, platelet type antibody
    • Alpha-2A adrenergic receptor antibody
    • Alpha-2A adrenoceptor antibody
    • Alpha-2A adrenoreceptor antibody
    • Alpha-2AAR antibody
    • ALPHA2AAR antibody
    • OTTHUMP00000058849 antibody
    • ZNF32 antibody
    see all

Anti-alpha 2a Adrenergic Receptor antibody 画像

  • ab45871 staining alpha 2a Adrenergic Receptor in mouse DRG neurons by Immunocytochemistry/ Immunofluorescence. The ganglia were collected from postnatal day 0–3 pups of C57 BL/6 mice and enzymatically dissociated with medium containing 0.25% trypsin at 37°C. Dissociated neurons were then plated onto glasscoverslips and maintained at 37°C in culture media. After drug treatment, the cultures were fixed with 4% paraformaldehyde for 10 min, washed in phosphate-buffered saline (PBS), permeabilized, and preblocked with PBS containing 10% normal donkey serum and 0.1% Triton X-100 for 2 h at room temperature. The cultures were then incubated overnight at 4 °C with the primary antibodies. A Biotin-conjugated anti-goat IgG and Cy3-conjugated streptavidin was used to detect alpha 2a adrenergic receptor.

Anti-alpha 2a Adrenergic Receptor antibody (ab45871) 使用論文

This product has been referenced in:
  • Alba-Delgado C  et al. The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain. Psychopharmacology (Berl) : (2011). WB, IHC-FrFl ; Rat . Read more (PubMed: 22038538) »
  • Tan M  et al. p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons. J Biol Chem 284:6270-81 (2009). ICC/IF ; Mouse . Read more (PubMed: 19126537) »

See all 2 Publications for this product

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The blocking peptide for ab85570 is ab102061.

For ab45871, ab54291 can be used.