Anti-alpha 2 Macroglobulin 抗体 [EPR4432] (ab109422)


  • 製品名Anti-alpha 2 Macroglobulin antibody [EPR4432]
    alpha 2 Macroglobulin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR4432] to alpha 2 Macroglobulin
  • アプリケーション適用あり: WB, IHC-Pmore details
    適用なし: Flow Cyt,ICC or IP
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human alpha 2 Macroglobulin.

  • ポジティブ・コントロール
    • Human plasma lysate; Human liver tissue
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.




Our Abpromise guarantee covers the use of ab109422 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 163 kDa.
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
  • 追加情報Is unsuitable for Flow Cyt,ICC or IP.
  • ターゲット情報

    • 機能Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
    • 組織特異性Secreted in plasma.
    • 配列類似性Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
    • 発生段階Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • A2m antibody
      • A2MG_HUMAN antibody
      • Alpha 2 M antibody
      • Alpha 2M antibody
      • Alpha-2-M antibody
      • Alpha-2-macroglobulin antibody
      • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody
      • CPAMD5 antibody
      • DKFZp779B086 antibody
      • FWP007 antibody
      • S863 7 antibody
      see all

    Anti-alpha 2 Macroglobulin antibody [EPR4432] 画像

    • Anti-alpha 2 Macroglobulin antibody [EPR4432] (ab109422) at 1/1000 dilution + Human plasma lysate at 10 µg

      Predicted band size : 163 kDa
    • ab109422, at 1/500 dilution, staining alpha 2 Macroglobulin in paraffin-embedded Human liver by Immunohistochemistry.

    Anti-alpha 2 Macroglobulin antibody [EPR4432] (ab109422) 使用論文

    ab109422 has not yet been referenced specifically in any publications.

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