製品の概要

  • 製品名Anti-alpha 2 Catenin antibody
    alpha 2 Catenin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to alpha 2 Catenin
  • 特異性Anti-alpha-N-Catenin recognizes alpha-N-catenin (102 kDa) by immunoblotting. Staining of the alpha-N-catenin band in immunoblotting is specifically inhibited with the alpha-N-catenin immunizing peptide (human, amino acids 171-186).
  • アプリケーション適用あり: IHC-Fr, WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Chicken
  • 免疫原

    Synthetic peptide:

    DLANRFKEFGKKMVKL

    conjugated to KLH, corresponding to amino acids 171-186 of Human alpha 2 Catenin.

  • 特記事項Storage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab11347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr
WB
  • 追加情報IHC-Fr: 1/500.
    WB: 1/1000 - 1/2000. Detects a band of approximately 102 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.
    • 配列類似性Belongs to the vinculin/alpha-catenin family.
    • 細胞内局在Cytoplasm. Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cell projection > axon. Recruited to the nucleus upon ZNF639 overexpression.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Alpha catenin related protein antibody
      • Alpha N catenin antibody
      • Alpha N-catenin antibody
      • Alpha-catenin-related protein antibody
      • Cadherin associated protein related antibody
      • Cancer/testis antigen 114 antibody
      • CAP R antibody
      • CAPR antibody
      • Catenin (cadherin associated protein) alpha 2 antibody
      • Catenin alpha 2 antibody
      • Catenin alpha-2 antibody
      • CT114 antibody
      • CTNA2_HUMAN antibody
      • CTNN A2 antibody
      • CTNNA 2 antibody
      • CTNNA2 antibody
      • CTNR antibody
      • DKFZp686H02198 antibody
      see all

    Anti-alpha 2 Catenin antibody 画像

    • ab11347 staining alpha 2 Catenin (left) in Mouse cortical ventricular zone tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with 4% paraformaldehyde in PBS overnight at 4°C, then saturated in 30% sucrose at 4°C (for at least 18 hours). Fixed and saturated brains were embedded in OCT compound and frozen rapidly with dry ice, and then 12µm cyrosections collected and stored at -80°C. Samples were incubated with primary antibody (1/500). Middle - non-phosphorylated active beta catenin, Right - merge. Beta catenin co-localizes with alpha catenin at the apical junctions rings.

    Anti-alpha 2 Catenin antibody (ab11347) 使用論文

    This product has been referenced in:
    • Butko MT  et al. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Proc Natl Acad Sci U S A 110:E726-35 (2013). WB ; Mouse . Read more (PubMed: 23382246) »
    • Thompson J  et al. Adherens junction breakdown in the periderm following cadmium administration in the chick embryo: distribution of cadherins and associated molecules. Reprod Toxicol 25:39-46 (2008). IHC-P ; Chicken . Read more (PubMed: 18031986) »

    See all 3 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"