Anti-alpha 1 Spectrin 抗体 [AF10] (ab86184)

製品の概要

  • 製品名Anti-alpha 1 Spectrin antibody [AF10]
    alpha 1 Spectrin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [AF10] to alpha 1 Spectrin
  • 特異性ab86184 is specific to the erythroid alpha 1 Spectrin.
  • アプリケーション適用あり: WB, IP, ICCmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Ghost proteins of human red blood cells.

  • 特記事項


    ab86184 is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 280 kDa.
IP Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.

ターゲット情報

  • 機能Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
  • 関連疾患Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2) [MIM:130600]. EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
    Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
    Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3) [MIM:270970]; also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive.
  • 配列類似性Belongs to the spectrin family.
    Contains 3 EF-hand domains.
    Contains 1 SH3 domain.
    Contains 21 spectrin repeats.
  • 細胞内局在Cytoplasm > cytoskeleton. Cytoplasm > cell cortex.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Alpha I spectrin antibody
    • EL 2 antibody
    • EL2 antibody
    • Elliptocytosis 2 antibody
    • Elliptocytosis2 antibody
    • Erythrocyte alpha spectrin antibody
    • erythrocyte antibody
    • Erythroid alpha spectrin antibody
    • Erythroid alpha-spectrin antibody
    • Erythroid spectrin alpha antibody
    • HPP antibody
    • HS3 antibody
    • Spectrin alpha chain antibody
    • Spectrin alpha chain erythrocyte antibody
    • Spectrin alpha erythrocytic 1 antibody
    • SPH3 antibody
    • SPTA 1 antibody
    • SPTA antibody
    • SPTA1 antibody
    • SPTA1_HUMAN antibody
    see all

Anti-alpha 1 Spectrin antibody [AF10] (ab86184) 使用論文

ab86184 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab86184.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"