Anti-alpha 1 Catenin 抗体 (ab37762)

製品の概要

• 製品名
  Anti-alpha 1 Catenin antibody
  alpha 1 Catenin 一次抗体 製品一覧
• 製品の詳細
  Chicken polyclonal to alpha 1 Catenin
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Mouse, Rat, Human, Chimpanzee
  
• 免疫原

  Synthetic peptide, corresponding to N terminal amino acids 2 - 200 of Human alpha 1 Catenin

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファー
  Preservative: None
  Constituents: PBS
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgY
• 研究分野
  • Signal Transduction
  • Cytoskeleton / ECM
  • Cell Adhesion
  • Cadherins

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cytoskeleton
  • Microfilaments
  • Actin etc
  • Catenins

  • Stem Cells
  • Signaling Pathways
  • Wnt
  • Cytoplasmic

  • Cancer
  • Invasion/microenvironment
  • ECM
  • Cell adhesion
  • Cadherins

関連製品

• Corresponding Antibody
  • Rabbit Anti-Chicken IgY H&L (Alkaline Phosphatase) (ab6754)
  • Goat Anti-Chicken IgY H&L (FITC) (ab6873)

アプリケーション

ターゲット情報

• 機能
  Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
• 組織特異性
  Expressed ubiquitously in normal tissues.
• 配列類似性
  Belongs to the vinculin/alpha-catenin family.
• 翻訳後修飾
  Sumoylated.
• 細胞内局在
  Cell membrane and Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.

• Target information above from: UniProt accession P35221 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 1495 Human
  • Entrez Gene: 12385 Mouse
  • Entrez Gene: 307505 Rat
  • Omim: 116805 Human
  • SwissProt: P35221 Human
  • SwissProt: P26231 Mouse
  • Unigene: 445981 Human
  • Unigene: 656653 Human

  • Unigene: 18962 Mouse

  see all
• 別名
  • Alpha E-catenin antibody
  • Cadherin associated protein 102kDa antibody
  • Cadherin associated protein antibody

  • Cadherin-associated protein antibody
  • CAP 102 antibody
  • CAP102 antibody
  • Catenin (cadherin associated protein) alpha 1 102kDa antibody
  • Catenin (cadherin associated protein), alpha 1, 102kDa antibody
  • Catenin alpha 1 antibody
  • Catenin alpha-1 antibody
  • CTNA1_HUMAN antibody
  • CTNNA 1 antibody
  • Ctnna1 antibody
  • FLJ36832 antibody
  • FLJ52416 antibody
  • MDPT2 antibody
  • NY REN 13 antigen antibody
  • OTTHUMP00000224141 antibody
  • OTTHUMP00000224147 antibody
  • Renal carcinoma antigen NY REN 13 antibody
  • Renal carcinoma antigen NY-REN-13 antibody

  see all

プロトコール

• Western blot protocols