製品の概要

  • 製品名
    Anti-alpha 1 Catenin antibody
    alpha 1 Catenin 一次抗体 製品一覧
  • 製品の詳細
    Chicken polyclonal to alpha 1 Catenin
  • 由来種
    Chicken
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human, Chimpanzee
  • 免疫原

    Synthetic peptide, corresponding to N terminal amino acids 2 - 200 of Human alpha 1 Catenin

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab37762 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000. Predicted molecular weight: 100 kDa.

ターゲット情報

  • 機能
    Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
  • 組織特異性
    Expressed ubiquitously in normal tissues.
  • 配列類似性
    Belongs to the vinculin/alpha-catenin family.
  • 翻訳後修飾
    Sumoylated.
  • 細胞内局在
    Cell membrane and Cytoplasm > cytoskeleton. Cell junction > adherens junction. Cell membrane. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries.
  • Information by UniProt
  • 参照データベース
    see all
  • 別名
    • Alpha E-catenin antibody
    • Cadherin associated protein 102kDa antibody
    • Cadherin associated protein antibody
    • Cadherin-associated protein antibody
    • CAP 102 antibody
    • CAP102 antibody
    • Catenin (cadherin associated protein) alpha 1 102kDa antibody
    • Catenin (cadherin associated protein), alpha 1, 102kDa antibody
    • Catenin alpha 1 antibody
    • Catenin alpha-1 antibody
    • CTNA1_HUMAN antibody
    • CTNNA 1 antibody
    • Ctnna1 antibody
    • FLJ36832 antibody
    • FLJ52416 antibody
    • MDPT2 antibody
    • NY REN 13 antigen antibody
    • OTTHUMP00000224141 antibody
    • OTTHUMP00000224147 antibody
    • Renal carcinoma antigen NY REN 13 antibody
    • Renal carcinoma antigen NY-REN-13 antibody
    see all

画像

  • Western blot - alpha 1 Catenin antibody (ab37762)
    Western blot - alpha 1 Catenin antibody (ab37762)
    Anti-alpha 1 Catenin antibody (ab37762) at 1/2000 dilution + E. coli derived fusion protein at 2.5 µg

    Secondary
    HRP conjugated Goat anti IgY at 1/1000 dilution

    Predicted band size: 100 kDa



    The use of a fusion protein is the reason for the difference in molecular weight detected.

プロトコール

参考文献

ab37762 has not yet been referenced specifically in any publications.

ab37762 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

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