Anti-alpha 1 Antichymotrypsin 抗体 (ab88527)

製品の概要

  • 製品名Anti-alpha 1 Antichymotrypsin antibody
    alpha 1 Antichymotrypsin 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to alpha 1 Antichymotrypsin
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length Human alpha 1 Antichymotrypsin protein (NP_001076.2).

  • ポジティブ・コントロール
    • WB: HeLa cell lysate and alpha 1 Antichymotrypsin transfected 293T cell lysate IF: HeLa cell

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab88527 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 48 kDa.
ICC/IF Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
  • 組織特異性Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
  • 関連疾患Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
  • 配列類似性Belongs to the serpin family.
  • ドメインThe reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • SERPINA3 antibody
    • AACT antibody
    • AACT_HUMAN antibody
    • ACT antibody
    • Alpha-1-antichymotrypsin His-Pro-less antibody
    • Antichymotrypsin antibody
    • Cell growth inhibiting gene 24/25 protein antibody
    • Cell growth-inhibiting gene 24/25 protein antibody
    • GIG24 antibody
    • GIG25 antibody
    • Growth inhibiting protein 24 antibody
    • Growth inhibiting protein 25 antibody
    • MGC88254 antibody
    • Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3 antibody
    • Serine (or cysteine) proteinase inhibitor clade A member 3 antibody
    • Serine proteinase inhibitor clade A member 3 antibody
    • Serpin A3 antibody
    • Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3 antibody
    • SERPINA3 antibody
    see all

Anti-alpha 1 Antichymotrypsin antibody 画像

  • Anti-alpha 1 Antichymotrypsin antibody (ab88527) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 48 kDa
    Observed band size : 48 kDa
  • All lanes : Anti-alpha 1 Antichymotrypsin antibody (ab88527) at 1 µg/ml

    Lane 1 : alpha 1 Antichymotrypsin transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 48 kDa
    Observed band size : 47 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 60 kDa. We are unsure as to the identity of these extra bands.
  • ab88527 at 10 µg/ml staining alpha 1 Antichymotrypsin in paraformaldehyde fixed, permeabilised HeLa cells, by immunofluorescence.

Anti-alpha 1 Antichymotrypsin antibody (ab88527) 使用論文

ab88527 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"