The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Dilute in PBS or medium which is identical to that used in the assay system.
May be used in immunoassays to detect and quantitate alpha-1-antichymotrypsin.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
組織特異性Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
関連疾患Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) [MIM:107280].
配列類似性Belongs to the serpin family.
ドメインThe reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.