製品の概要

  • 製品名Anti-ALOX12B antibody
    ALOX12B 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ALOX12B
  • アプリケーション適用あり: ICC/IF, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 423-516 (LYKLLIPHTR YTVQINSIGR AVLLNEGGLS AKGMSLGVEG FAGVMVRALS ELTYDSLYLP NDFVERGVQD LPGYYYRDDS LAVWNALEKY VTEI) of Human ALOX12B.

  • ポジティブ・コントロール
    • Human skin tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab121785 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Converts arachidonic acid to 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE).
  • 組織特異性Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue.
  • パスウェイLipid metabolism; leukotriene D4 biosynthesis.
  • 関連疾患Defects in ALOX12B are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE) [MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
  • 配列類似性Belongs to the lipoxygenase family.
    Contains 1 lipoxygenase domain.
    Contains 1 PLAT domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 12R-lipoxygenase antibody
    • 12R-LOX antibody
    • 12R-type antibody
    • Alox12b antibody
    • Arachidonate 12-lipoxygenase antibody
    • Epidermis-type lipoxygenase 12 antibody
    • LX12B_HUMAN antibody
    see all

Anti-ALOX12B antibody 画像

  • Immunofluorescent staining of Human cell line U-2 OS shows positivity in cytoplasm. Recommended concentration of ab121785 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab121785, at 1/10 dilution, staining ALOX12B in paraffin-embedded Human skin tissue, by Immunohistochemistry.

Anti-ALOX12B antibody (ab121785) 使用論文

ab121785 has not yet been referenced specifically in any publications.

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