製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to ALMS1
  • アプリケーション
    適用あり: ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 1200-1250 of human ALMS1 (EAW99731.1).

  • ポジティブ・コントロール
    • HeLa Cells.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab84892 was affinity purified using an epitope specific to ALMS1 immobilized on solid support.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF
  • 追加情報
    ICC/IF: 1/100 - 1/500. Formaldehyde fixation and permeabilization with Triton-X 100 is recommended.

    Acetone fixation is not recommended.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Possible role in intracellular trafficking.
    • 組織特異性
      Expressed in all tissues tested including adipose and pancreas. Expressed by beta-cells of the islets in the pancreas (at protein level).
    • 関連疾患
      Defects in ALMS1 are the cause of Alstrom syndrome (ALMS) [MIM:203800]. Alstrom syndrome is a rare autosomal recessive disorder characterized by progressive cone-rod retinal dystrophy, neurosensory hearing loss, early childhood obesity and type 2 diabetes mellitus. Dilated cardiomyopathy, acanthosis nigricans, male hypogonadism, hypothyroidism, developmental delay and hepatic dysfunction can also be associated with the syndrome.
    • 発生段階
      Widely expressed in fetal tissues. Detected in fetal pancreas, skeletal muscle, liver, kidney and brain (at protein level). Expressed in fetal aorta and brain.
    • 翻訳後修飾
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在
      Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > spindle pole. Associated with centrosomes and basal body at the base of primary cilia. During mitosis localizes to both spindle poles.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Alms1 antibody
      • ALMS1_HUMAN antibody
      • ALSS antibody
      • Alstrom syndrome 1 antibody
      • Alstrom syndrome protein 1 antibody
      see all

    Anti-ALMS1 antibody 画像

    • ab84892, at a 1/250 dilution, staining ALMS1 in NBF fixed asynchronous HeLa cells by Immunocytochemistry.
      Detection by Red fluorescent goat anti-rabbit IgG highly cross adsorbed antibody used at a dilution of 1/100.

    Anti-ALMS1 antibody (ab84892) 使用論文

    This product has been referenced in:
    • Chen JH  et al. Truncation of POC1A associated with short stature and extreme insulin resistance. J Mol Endocrinol 55:147-58 (2015). ICC/IF ; Human . Read more (PubMed: 26336158) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab84892.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    登録