製品の概要

  • 製品名Anti-ALMS1 antibody
    ALMS1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to ALMS1
  • アプリケーション適用あり: ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 1200-1250 of human ALMS1 (EAW99731.1).

  • ポジティブ・コントロール
    • HeLa Cells.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab84892 was affinity purified using an epitope specific to ALMS1 immobilized on solid support.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab84892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF
  • 追加情報ICC/IF: 1/100 - 1/500. Formaldehyde fixation and permeabilization with Triton-X 100 is recommended.

    Acetone fixation is not recommended.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Possible role in intracellular trafficking.
    • 組織特異性Expressed in all tissues tested including adipose and pancreas. Expressed by beta-cells of the islets in the pancreas (at protein level).
    • 関連疾患Defects in ALMS1 are the cause of Alstrom syndrome (ALMS) [MIM:203800]. Alstrom syndrome is a rare autosomal recessive disorder characterized by progressive cone-rod retinal dystrophy, neurosensory hearing loss, early childhood obesity and type 2 diabetes mellitus. Dilated cardiomyopathy, acanthosis nigricans, male hypogonadism, hypothyroidism, developmental delay and hepatic dysfunction can also be associated with the syndrome.
    • 発生段階Widely expressed in fetal tissues. Detected in fetal pancreas, skeletal muscle, liver, kidney and brain (at protein level). Expressed in fetal aorta and brain.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > spindle pole. Associated with centrosomes and basal body at the base of primary cilia. During mitosis localizes to both spindle poles.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Alms1 antibody
      • ALMS1_HUMAN antibody
      • ALSS antibody
      • Alstrom syndrome 1 antibody
      • Alstrom syndrome protein 1 antibody
      see all

    Anti-ALMS1 antibody 画像

    • ab84892, at a 1/250 dilution, staining ALMS1 in NBF fixed asynchronous HeLa cells by Immunocytochemistry.
      Detection by Red fluorescent goat anti-rabbit IgG highly cross adsorbed antibody used at a dilution of 1/100.

    Anti-ALMS1 antibody (ab84892) 使用論文

    ab84892 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab84892.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"