機能Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
組織特異性Widely expressed, with highest expression in spleen, followed by pancreas and lung.
配列類似性Belongs to the alkB family. Contains 1 Fe2OG dioxygenase domain. Contains 1 RRM (RNA recognition motif) domain.