Anti-ALIX 抗体 (ab50249)

製品の概要

• 製品名
  Anti-ALIX antibody
  ALIX 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to ALIX
• 特異性
  This antibody reacts specifically with the 91-93kDa ALIX.
• アプリケーション
  適用あり: IHC-P, WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Recombinant full length protein corresponding to Human ALIX.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファー
  Preservative: None
  Constituents: Whole serum
• 精製度
  Whole antiserum
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Cell Biology
  • Apoptosis
  • Extracellular Signals
  • Death Ligands

  • Microbiology
  • Interspecies Interaction
  • Host Virus Interaction

  • Signal Transduction
  • Protein Trafficking
  • Vesicle Transport
  • Regulation

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.
• 配列類似性
  Contains 1 BRO1 domain.
• 細胞内局在
  Cytoplasm > cytosol. Melanosome. Cytoplasm > cytoskeleton > centrosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells.

• Target information above from: UniProt accession Q8WUM4 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 10015 Human
  • Omim: 608074 Human
  • SwissProt: Q8WUM4 Human
  • Unigene: 475896 Human
• 別名
  • AIP1 antibody
  • ALG 2 interacting protein 1 antibody
  • ALG-2-interacting protein 1 antibody

  • ALG2 interacting protein X antibody
  • Alix antibody
  • Apoptosis linked gene 2 interacting protein X antibody
  • Dopamine receptor interacting protein 4 antibody
  • DRIP4 antibody
  • Hp95 antibody
  • KIAA1375 antibody
  • MGC17003 antibody
  • PDC6I_HUMAN antibody
  • PDCD6 interacting protein antibody
  • PDCD6-interacting protein antibody
  • PDCD6IP antibody
  • Programmed cell death 6 interacting protein antibody
  • Programmed cell death 6-interacting protein antibody

  see all

プロトコール

• Western blot protocols
• Immunohistochemistry protocols