製品の概要

  • 製品名Anti-AKR7A2 antibody
    AKR7A2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to AKR7A2
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 84 - 357 of Human AKR7A2 (NP_003680).

  • ポジティブ・コントロール
    • WB: 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cell lysates IF: HeLa cells

法規制情報

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab97458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.
ICC/IF 1/100 - 1/200.

ターゲット情報

  • 機能Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
  • 組織特異性Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.
  • 配列類似性Belongs to the aldo/keto reductase 2 family.
  • 細胞内局在Golgi apparatus. Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AFAR antibody
    • AFAR1 antibody
    • AFB1 aldehyde reductase 1 antibody
    • AFB1 AR1 antibody
    • AFB1-AR 1 antibody
    • AFB1AR1 antibody
    • Aflatoxin aldehyde reductase antibody
    • Aflatoxin B1 aldehyde reductase member 2 antibody
    • Aflatoxin beta1 aldehyde reductase antibody
    • Aiar antibody
    • AKR7 antibody
    • Akr7a2 antibody
    • Aldo keto reductase family 7 antibody
    • Aldo keto reductase family 7 member A2 aflatoxin aldehyde reductase antibody
    • Aldo keto reductase family 7 member A2 antibody
    • Aldo keto reductase family 7, member A2 (aflatoxin aldehyde reductase) antibody
    • Aldoketoreductase 7 antibody
    • ARK72_HUMAN antibody
    • SSA reductase antibody
    • Succinic semialdehyde reductase antibody
    see all

Anti-AKR7A2 antibody 画像

  • Anti-AKR7A2 antibody (ab97458) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 40 kDa
  • ab97458, at a 1/200 dilution, staining AKR7A2 in paraformaldehyde-fixed HeLa cells by Immunofluorescence analysis. Right image is merged with a DNA probe.

Anti-AKR7A2 antibody (ab97458) 使用論文

ab97458 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Tissue lysate - whole (Heart)
Loading amount 50 µg
Specification Heart
Gel Running Conditions Non-reduced Denaturing (12% Tris/glycine gel)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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投稿 Nov 16 2012

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"