製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to AKR1C3
  • アプリケーション
    適用あり: WB, IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Cow, Human
  • 免疫原

    A 15 amino acid peptide corresponding to the C terminal residues of human AKR1C3 (P42330).

  • ポジティブ・コントロール
    • Human fetal liver lysates; human lung tissue; HeLa cells.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 36 kDa.
IHC-P 1/100 - 1/500.
ICC/IF 1/50 - 1/200.

ターゲット情報

  • 機能
    Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
  • 組織特異性
    Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
  • 配列類似性
    Belongs to the aldo/keto reductase family.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 17 beta HSD 5 antibody
    • 17 beta hydroxysteroid dehydrogenase type 5 antibody
    • 17-beta-HSD 5 antibody
    • 17-beta-hydroxysteroid dehydrogenase type 5 antibody
    • 2-dihydrobenzene-1 antibody
    • 2-diol dehydrogenase antibody
    • 20-alpha-hydroxysteroid dehydrogenase antibody
    • 3 alpha hydroxysteroid dehydrogenase type II antibody
    • 3-alpha-HSD type 2 antibody
    • 3-alpha-HSD type II antibody
    • 3-alpha-HSD type II, brain antibody
    • 3-alpha-hydroxysteroid dehydrogenase type 2 antibody
    • AK1C3_HUMAN antibody
    • AKR1 C3 antibody
    • Akr1c18 antibody
    • AKR1C3 antibody
    • Aldo keto reductase family 1 member C3 antibody
    • Aldo-keto reductase family 1 member C3 antibody
    • brain antibody
    • Chlordecone reductase antibody
    • Chlordecone reductase homolog HAKRb antibody
    • DD-3 antibody
    • DD3 antibody
    • DDH1 antibody
    • DDX antibody
    • Dihydrodiol dehydrogenase 3 antibody
    • Dihydrodiol dehydrogenase type I antibody
    • Dihydrodiol dehydrogenase X antibody
    • HA1753 antibody
    • HAKRB antibody
    • HAKRe antibody
    • hluPGFS antibody
    • HSD17B5 antibody
    • Indanol dehydrogenase antibody
    • KIAA0119 antibody
    • PGFS antibody
    • Prostaglandin F synthase antibody
    • Testosterone 17-beta-dehydrogenase 5 antibody
    • Trans-1 antibody
    • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase antibody
    • Type IIb 3 alpha hydroxysteroid dehydrogenase antibody
    see all

画像

  • Anti-AKR1C3 antibody (ab84327) at 1/500 dilution + human fetal liver lysate

    Predicted band size : 36 kDa
    Observed band size : 36 kDa
  • ab84327, at a 1/50 dilution, staining AKR1C3 in HeLa cells by Immunofluorescence.
  • ab84327, at a 1/100 dilution, staining AKR1C3 in formalin fixed, paraffin embedded human lung tissue by Immunohistochemistry. Note cytoplasmic staining.

参考文献

This product has been referenced in:
  • Wu CH  et al. Clinical implications of aldo-keto reductase family 1 member C3 and its relationship with lipocalin 2 in cancer of the uterine cervix. Gynecol Oncol 132:474-82 (2014). IHC-P ; Human . Read more (PubMed: 24316309) »
  • Kowalczyk-Zieba I  et al. Influence of lysophosphatidic acid on nitric oxide-induced luteolysis in steroidogenic luteal cells in cows. Biol Reprod 90:17 (2014). Cow . Read more (PubMed: 24307705) »

See all 6 Publications for this product

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