製品の概要

  • 製品名Anti-AKR1A1 antibody
    AKR1A1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to AKR1A1
  • アプリケーション適用あり: IHC-P, ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide: DAGHPLYPFNDPY, corresponding to amino acids 312-324 of Human AKR1A1.

  • ポジティブ・コントロール
    • Human Placenta and Liver lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab11802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 2 - 3 µg/ml.
ELISA 1/16000. This application has only been tested against the recombinant protein.
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 37 kDa.Can be blocked with Human AKR1A1 peptide (ab23210). Approx 37-40kDa band observed in Human Placenta and Liver lysates.

ターゲット情報

  • 機能Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
  • 組織特異性Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
  • 配列類似性Belongs to the aldo/keto reductase family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AK1A1_HUMAN antibody
    • Akr1a1 antibody
    • Alcohol dehydrogenase [NADP+] antibody
    • Alcohol dehydrogenase antibody
    • Aldehyde reductase antibody
    • Aldo keto reductase family 1 member A1 (aldehyde reductase) antibody
    • Aldo-keto reductase family 1 member A1 antibody
    • ALDR1 antibody
    • ALR antibody
    • ARM antibody
    • DD3 antibody
    • MGC12529 antibody
    • MGC1380 antibody
    see all

Anti-AKR1A1 antibody 画像

  • Anti-AKR1A1 antibody (ab11802) at 0.1 µg/ml + Human Liver lysate (in RIPA buffer) at 35 µg

    Predicted band size : 37 kDa
    Observed band size : 37 kDa
  • ab11802 at 2.5µg/ml, staining AKR1A1 in Human Kidney sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with pH 6 citrate buffer was performed, and AP-staining was used.

Anti-AKR1A1 antibody (ab11802) 使用論文

This product has been referenced in:
  • Singh S  et al. SMAR1 regulates free radical stress through modulation of AKR1a4 enzyme activity. Int J Biochem Cell Biol 42:1105-14 (2010). Read more (PubMed: 20097305) »
  • Diggle CP  et al. Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem 57:763-74 (2009). Read more (PubMed: 19365088) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"