Goat polyclonal to AKAP12
ab118365 is expected to recognize isoform 1 (NP_005091.2) only.
with a Cysteine residue linker, corresponding to internal sequence amino acids 1645-1658 of Mouse AKAP12 (NP_112462.1).
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Concentration information loading...
Immunogen affinity purified
ab118365 is purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
||Use at an assay dependent concentration.
Is unsuitable for WB.
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
Contains 3 AKAP domains.
Polybasic regions located between residues 266 and 557 are involved in binding PKC.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cytoplasm > cell cortex. Cytoplasm > cytoskeleton. May be part of the cortical cytoskeleton.
Information by UniProt
- A kinase (PRKA) anchor protein (gravin) 12 antibody
- A kinase Anchor Protein 12 antibody
- A kinase anchor protein 250kDa antibody
has not yet been referenced specifically in any publications.
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