Anti-AKAP10 抗体 (ab97354)

製品の概要

• 製品名Anti-AKAP10 antibody
  AKAP10 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to AKAP10
• アプリケーション適用あり: WB, IHC-Pmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide corresponding to a region within amino acids 600-662 (ESEPEPDVRK SKGSMFSQAM KKWVQGNTDE AQEELAWKIA KMIVSDIMQQ AQYDQPLEKS TKL) of Human AKAP10

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • HeLa, HepG2 cells. OVCAR3 tissue, T(gastric CA) tissue.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファーPreservative: 0.01% Thimerosal (merthiolate)
  Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Signal Transduction
  • Protein Phosphorylation
  • Ser / Thr Kinases
  • PKA

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa whole cell lysate (ab29545)
  • HepG2 whole cell lysate (ab7900)

アプリケーション

ターゲット情報

• 機能Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
• 関連疾患Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:115080]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.
• 配列類似性Contains 2 RGS domains.
• ドメインRII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
• 細胞内局在Mitochondrion. Membrane. Cytoplasm. Predominantly mitochondrial but also membrane associated and cytoplasmic.

• Target information above from: UniProt accession O43572 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 11216 Human
  • Omim: 604694 Human
  • SwissProt: O43572 Human
  • Unigene: 642676 Human
• 別名
  • 1500031L16Rik antibody
  • A kinase (PRKA) anchor protein 10 antibody
  • A kinase anchor protein 10 antibody

  • A kinase anchor protein 10 mitochondrial antibody
  • A-kinase anchor protein 10 antibody
  • AKA10_HUMAN antibody
  • akap 10 antibody
  • AKAP-10 antibody
  • AKAP10 antibody
  • B130049N18Rik antibody
  • D AKAP 2 antibody
  • D-AKAP-2 antibody
  • dakap 2 antibody
  • dakap2 antibody
  • Dual specific A kinase anchoring protein 2 antibody
  • Dual specificity A kinase-anchoring protein 2 antibody
  • mgc9410 antibody
  • MGC9414| antibody
  • Mitochondrial A kinase PPKA anchor protein 10 antibody
  • mitochondrial antibody
  • prka 10 antibody
  • PRKA10 antibody
  • Protein A kinase anchoring protein 10 antibody
  • Protein A kinase anchoring protein 10 mitochondrial precursor antibody
  • Protein kinase A anchoring protein 10 antibody
  • Protein kinase A-anchoring protein 10 antibody

  see all