製品の概要

  • 製品名Anti-AK2 antibody
    AK2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to AK2
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to Human AK2.
    Database link: NM_001625

  • ポジティブ・コントロール
    • Human fetal kidney lysate and hepatocarcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab93856 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
  • 追加情報IHC-P: 1/100 - 1/500.
    WB: 1/200 - 1/1000. Predicted molecular weight: 26 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis.
    • 組織特異性Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
    • 関連疾患Defects in AK2 are the cause of reticular dysgenesis (RDYS) [MIM:267500]; also known as aleukocytosis. RDYS is the most severe form of inborn severe combined immunodeficiencies (SCID) and is characterized by absence of granulocytes and almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immune functions, leading to fatal septicemia within days after birth. In bone marrow of individuals with reticular dysgenesis, myeloid differentiation is blocked at the promyelocytic stage, whereas erythro- and megakaryocytic maturation is generally normal.In addition, affected newborns have bilateral sensorineural deafness. Defects may be due to its absence in leukocytes and inner ear, in which its absence can not be compensated by AK1.
    • 配列類似性Belongs to the adenylate kinase family. AK2 subfamily.
    • 細胞内局在Mitochondrion intermembrane space.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Adenylate kinase 2 antibody
      • adenylate kinase 2, mitochondrial antibody
      • Adenylate kinase isoenzyme 2 antibody
      • ADK2 antibody
      • AK 2 antibody
      • ak2 antibody
      • ATP AMP transphosphorylase antibody
      • ATP-AMP transphosphorylase 2 antibody
      • EC 2.7.4.3 antibody
      • KAD2_HUMAN antibody
      • mitochondrial antibody
      see all

    Anti-AK2 antibody 画像

    • ab93856, at a 1/100 dilution, showing cytoplasmic staining of Human AK2 in hepatocarcinoma tissue, by Immunohistochemistry, (Formalin/PFA-fixed paraffin-embedded).
    • Anti-AK2 antibody (ab93856) at 1/500 dilution + Fetal kidney lysate

      Predicted band size : 26 kDa

    Anti-AK2 antibody (ab93856) 使用論文

    ab93856 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab93856.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"