製品の概要

製品の詳細

  • 由来Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab7869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

関連情報

  • 別名
    • AIFM1
    • AIFM1_HUMAN
    • Apoptosis inducing factor
    • Apoptosis inducing factor 1, mitochondrial
    • Apoptosis inducing factor, mitochondrion associated, 1
    • Apoptosis-inducing factor 1
    • CMTX4
    • COWCK
    • COXPD6
    • Harlequin
    • Hq
    • mAIF
    • MGC111425
    • MGC5706
    • mitochondrial
    • Neuropathy, axonal motor-sensory, with deafness and mental retardation
    • neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome)
    • PDCD 8
    • PDCD8
    • Programmed cell death 8
    • Programmed cell death 8 (apoptosis inducing factor)
    • Programmed cell death 8 isoform 1
    • Programmed cell death 8 isoform 2
    • Programmed cell death 8 isoform 3
    • Programmed cell death protein 8
    • Programmed cell death protein 8 mitochondrial
    • Programmed cell death protein 8 mitochondrial precursor
    • Striatal apoptosis inducing factor
    see all
  • 機能Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
  • 関連疾患Defects in AIFM1 are the cause of combined oxidative phosphorylation deficiency type 6 (COXPD6) [MIM:300816]. It is a mitochondrial disease resulting in a neurodegenerative disorder characterized by psychomotor delay, hypotonia, areflexia, muscle weakness and wasting.
  • 配列類似性Belongs to the FAD-dependent oxidoreductase family.
  • 翻訳後修飾Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocation into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner.
  • 細胞内局在Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Nucleus. Cytoplasm > perinuclear region. Proteolytic cleavage during or just after translocation into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region.
  • Information by UniProt

AIF peptide (ab7869) 使用論文

ab7869 has not yet been referenced specifically in any publications.

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