製品の概要

  • 製品名Anti-AICDA antibody
    AICDA 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to AICDA
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow, Dog
  • 免疫原

    Peptide with sequence

    RRKFLYQFKNVR

    -C, from the N terminus of human AICDA protein (NP_065712.1).

  • ポジティブ・コントロール
    • Human tonsil lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab77401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報Peptide ELISA: Use at an assay dependent dilution. Detection limit dilution 1:1,000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 24 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
    • 組織特異性Strongly expressed in lymph nodes and tonsils.
    • 関連疾患Defects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]; also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.
    • 配列類似性Belongs to the cytidine and deoxycytidylate deaminase family.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Activation induced cytidine deaminase antibody
      • Activation induced deaminase antibody
      • Activation-induced cytidine deaminase antibody
      • AICDA antibody
      • AICDA_HUMAN antibody
      • AID antibody
      • ARP 2 antibody
      • ARP2 antibody
      • CDA 2 antibody
      • CDA2 antibody
      • Cytidine aminohydrolase antibody
      • HIGM2 antibody
      • Integrated into Burkitt's lymphoma cell line Ramos antibody
      see all

    Anti-AICDA antibody 画像

    • Anti-AICDA antibody (ab77401) at 0.3 µg/ml + Human tonsil lysate in RIPA buffer at 35 µg
      Developed using the ECL technique

      Predicted band size : 24 kDa
      Observed band size : 26 kDa (why is the actual band size different from the predicted?)


      Exposure time : 1 hour

    Anti-AICDA antibody (ab77401) 使用論文

    ab77401 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab77401.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"