製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to AIBZIP
  • アプリケーション
    適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide: PSGRIRSVLHADEM, corresponding to C terminal amino acids 382-395 of Human AIBZIP.

  • ポジティブ・コントロール
    • Placental lysate.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
  • Concentration information loading...
  • 特記事項(精製)
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab2474 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 2.5 µg/ml.
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 45 kDa).Can be blocked with Human AIBZIP peptide (ab22911).

ターゲット情報

  • 機能
    Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements.
  • 組織特異性
    According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
  • 配列類似性
    Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • 翻訳後修飾
    N-glycosylated in the C-terminal region.
    Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region.
  • 細胞内局在
    Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane. May also be located in Golgi apparatus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 1700012K17Rik antibody
    • AIbZIP antibody
    • Androgen induced basic leucine zipper antibody
    • Androgen induced basic leucine zipper protein antibody
    • Androgen-induced basic leucine zipper protein antibody
    • ATCE1 antibody
    • Attaching to CRE like 1 antibody
    • Attaching to CRE-like 1 antibody
    • cAMP responsive element binding protein 1 antibody
    • cAMP responsive element binding protein 3 like 4 antibody
    • cAMP responsive element binding protein 4 antibody
    • cAMP responsive element-binding protein 3 like protein 4 antibody
    • cAMP-responsive element-binding protein 3-like protein 4 antibody
    • cAMP-responsive element-binding protein 4 antibody
    • CR3L4_HUMAN antibody
    • CREB 4 antibody
    • CREB-4 antibody
    • CREB3 antibody
    • CREB3L4 antibody
    • CREB4 antibody
    • Cyclic AMP responsive element binding protein 3 like protein 4 antibody
    • Cyclic AMP responsive element binding protein 4 antibody
    • Cyclic AMP-responsive element-binding protein 4 antibody
    • hJAL antibody
    • JAL antibody
    • mJAL antibody
    • Processed cyclic AMP-responsive element-binding protein 3-like protein 4 antibody
    • Tisp40 antibody
    • Tisp40alpha antibody
    • Tisp40beta antibody
    • Transcript induced in spermiogenesis protein 40 antibody
    see all

画像

  • Anti-AIBZIP antibody (ab2474) at 0.5 µg/ml + Human placental lysates at 35 µg
    Developed using the ECL technique

    Predicted band size : 45 kDa
  • ab2474 at 2.5ug/ml staining AIBZIP in human prostate tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in steam with citrate buffer (pH 6.0). The AP-staining procedure was used for detection.

参考文献

ab2474 has not yet been referenced specifically in any publications.

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