生理活性の詳細EP1 and EP2 antagonist (Ki values are 333 and 350 nM, respectively). Specific DP2 receptor antagonist (pA2 = 4.45).
保存方法Store at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
溶解性Soluble in DMSO to 1 mg/ml and in ethanol to 0.5 mg/ml
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Jones RL & Woodward DF Interaction of prostanoid EP3 and TP receptors in guinea-pig isolated aorta: contractile self-synergism of 11-deoxy-16,16-dimethyl PGE2. Br J Pharmacol162:521-31 (2011).
Read more (PubMed: 20955363) »
van der Merwe JQ et al. Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2. J Pharmacol Exp Ther329:747-52 (2009).
Read more (PubMed: 19190238) »
Kiriyama M et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol122:217-24 (1997).
Read more (PubMed: 9313928) »