製品の概要

  • 製品名Anti-AGRP antibody
    AGRP 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to AGRP
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Dog, Pig
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 100 to the C-terminus of Human AGRP.

  • ポジティブ・コントロール
    • This antibody gave a positive signal in human Hippocampus FFPE section.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
  • 組織特異性Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
  • 関連疾患Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • 配列類似性Contains 1 agouti domain.
  • ドメインThe presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
  • 細胞内局在Secreted. Golgi apparatus lumen.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Agouti related neuropeptide antibody
    • Agouti Related Protein Homolog antibody
    • Agouti-related protein antibody
    • Agrp antibody
    • AGRP_HUMAN antibody
    • AGRT antibody
    • ART antibody
    • ASIP2 antibody
    see all

Anti-AGRP antibody 画像

  • IHC image of AGRP staining in human Hippocampus FFPE section, performed on a BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab86956, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX

Anti-AGRP antibody (ab86956) 使用論文

ab86956 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"